diff --git a/setup.py b/setup.py
new file mode 100644
index 0000000..4208772
--- /dev/null
+++ b/setup.py
@@ -0,0 +1,191 @@
+# Part of the LLVM Project, under the Apache License v2.0 with LLVM Exceptions.
+# See https://llvm.org/LICENSE.txt for license information.
+# SPDX-License-Identifier: Apache-2.0 WITH LLVM-exception
+# Also available under a BSD-style license. See LICENSE.
+
+# Script for generating the mpact wheel.
+# ```
+# $ python setup.py bdist_wheel
+# ```
+# Environment variables you are probably interested in:
+#
+#   CMAKE_BUILD_TYPE:
+#       specify the build type: DEBUG/RelWithDebInfo/Release
+#
+#   MPACT_CMAKE_ALREADY_BUILT:
+#       the `MPACT_CMAKE_BUILD_DIR` directory has already been compiled,
+#       and the CMake compilation process will not be executed again.
+#       On CIs, it is often advantageous to re-use/control the CMake build directory.
+#
+# It is recommended to build with Ninja and ccache. To do so, set environment
+# variables by prefixing to above invocations:
+# ```
+# CMAKE_GENERATOR=Ninja CMAKE_C_COMPILER_LAUNCHER=ccache CMAKE_CXX_COMPILER_LAUNCHER=ccache
+# ```
+#
+# Implementation notes:
+# The contents of the wheel is just the contents of the `python_packages`
+# directory that our CMake build produces. We go through quite a bit of effort
+# on the CMake side to organize that directory already, so we avoid duplicating
+# that here, and just package up its contents.
+import os
+import pathlib
+import shutil
+import subprocess
+import sys
+
+from datetime import date
+from distutils.command.build import build as _build
+from setuptools import setup, Extension
+from setuptools.command.build_ext import build_ext
+from setuptools.command.build_py import build_py
+
+
+def _check_env_flag(name: str, default=None) -> bool:
+    return str(os.getenv(name, default)).upper() in ["ON", "1", "YES", "TRUE", "Y"]
+
+
+PACKAGE_VERSION = "".join(str(date.today()).split("-"))
+SRC_DIR = pathlib.Path(__file__).parent.absolute()
+CMAKE_BUILD_TYPE = os.getenv("CMAKE_BUILD_TYPE", "Release")
+MPACT_CMAKE_ALREADY_BUILT = _check_env_flag("MPACT_CMAKE_ALREADY_BUILT", False)
+MPACT_CMAKE_BUILD_DIR = os.path.join(SRC_DIR, "build")
+
+
+# Build phase discovery is unreliable. Just tell it what phases to run.
+class CustomBuild(_build):
+    def initialize_options(self):
+        _build.initialize_options(self)
+        # Make setuptools not steal the build directory name,
+        # because the mlir c++ developers are quite
+        # used to having build/ be for cmake
+        self.build_base = "setup_build"
+
+    def run(self):
+        self.run_command("build_py")
+        self.run_command("build_ext")
+        self.run_command("build_scripts")
+
+
+class CMakeBuild(build_py):
+    def cmake_build(self, cmake_build_dir):
+        llvm_dir = str(
+            SRC_DIR / "externals" / "torch-mlir" / "externals" / "llvm-project" / "llvm"
+        )
+        cmake_config_args = [
+            f"cmake",
+            f"-GNinja",
+            f"-DCMAKE_BUILD_TYPE=Release",
+            f"-DPython3_FIND_VIRTUALENV=ONLY",
+            f"-DLLVM_ENABLE_PROJECTS=mlir",
+            f"-DLLVM_EXTERNAL_PROJECTS='torch-mlir;mpact'",
+            f"-DLLVM_EXTERNAL_TORCH_MLIR_SOURCE_DIR='{SRC_DIR}/externals/torch-mlir'",
+            f"-DLLVM_EXTERNAL_MPACT_SOURCE_DIR='{SRC_DIR}'",
+            f"-DLLVM_TARGETS_TO_BUILD=host",
+            f"-DMLIR_ENABLE_BINDINGS_PYTHON=ON",
+            # Optimization options for building wheels.
+            f"-DCMAKE_VISIBILITY_INLINES_HIDDEN=ON",
+            f"-DCMAKE_C_VISIBILITY_PRESET=hidden",
+            f"-DCMAKE_CXX_VISIBILITY_PRESET=hidden",
+            f"{llvm_dir}",
+        ]
+
+        cmake_build_args = [
+            f"cmake",
+            f"--build",
+            f".",
+            f"--target",
+            f"MPACTPythonModules",
+            f"MPACTBenchmarkPythonPythonModules",
+        ]
+
+        try:
+            subprocess.check_call(cmake_config_args, cwd=cmake_build_dir)
+            subprocess.check_call(cmake_build_args, cwd=cmake_build_dir)
+        except subprocess.CalledProcessError as e:
+            print("cmake build failed with\n", e)
+            print("debug by follow cmake command:")
+            sys.exit(e.returncode)
+        finally:
+            print(f"cmake config: {' '.join(cmake_config_args)}")
+            print(f"cmake build: {' '.join(cmake_build_args)}")
+            print(f"cmake workspace: {cmake_build_dir}")
+            print(SRC_DIR)
+
+    def run(self):
+        target_dir = self.build_lib
+        cmake_build_dir = MPACT_CMAKE_BUILD_DIR
+        if not cmake_build_dir:
+            cmake_build_dir = os.path.abspath(os.path.join(target_dir, "..", "build"))
+
+        python_package_dir = os.path.join(
+            cmake_build_dir, "tools", "mpact", "python_packages", "mpact"
+        )
+        if not MPACT_CMAKE_ALREADY_BUILT:
+            os.makedirs(cmake_build_dir, exist_ok=True)
+            cmake_cache_file = os.path.join(cmake_build_dir, "CMakeCache.txt")
+            if os.path.exists(cmake_cache_file):
+                os.remove(cmake_cache_file)
+            # NOTE: With repeated builds for different Python versions, the
+            # prior version binaries will continue to accumulate. Here we just
+            # delete the directory where we build native extensions to keep
+            # this from happening but still take advantage of most of the
+            # build cache.
+            mlir_libs_dir = os.path.join(python_package_dir, "mpact", "_mlir_libs")
+            if os.path.exists(mlir_libs_dir):
+                print(f"Removing _mlir_mlibs dir to force rebuild: {mlir_libs_dir}")
+                shutil.rmtree(mlir_libs_dir)
+            else:
+                print(f"Not removing _mlir_libs dir (does not exist): {mlir_libs_dir}")
+            self.cmake_build(cmake_build_dir)
+
+        if os.path.exists(target_dir):
+            shutil.rmtree(target_dir, ignore_errors=False, onerror=None)
+
+        shutil.copytree(python_package_dir, target_dir, symlinks=False)
+
+
+class CMakeExtension(Extension):
+    def __init__(self, name, sourcedir=""):
+        Extension.__init__(self, name, sources=[])
+        self.sourcedir = os.path.abspath(sourcedir)
+
+
+class NoopBuildExtension(build_ext):
+    def build_extension(self, ext):
+        pass
+
+
+with open("README.md", "r", encoding="utf-8") as fh:
+    long_description = fh.read()
+
+
+# Requires and extension modules depend on whether building PyTorch
+# extensions.
+INSTALL_REQUIRES = [
+    "numpy",
+    "packaging",
+]
+EXT_MODULES = [
+    CMakeExtension("mpact._mlir_libs._mpact"),
+]
+
+setup(
+    name="mpact",
+    version=f"{PACKAGE_VERSION}",
+    author="Reid Tatge",
+    author_email="tatge@google.com",
+    description="MPACT retargetable ML compiler",
+    long_description=long_description,
+    long_description_content_type="text/markdown",
+    include_package_data=True,
+    cmdclass={
+        "build": CustomBuild,
+        "built_ext": NoopBuildExtension,
+        "build_py": CMakeBuild,
+    },
+    ext_modules=EXT_MODULES,
+    python_requires=">=3.8",
+    install_requires=INSTALL_REQUIRES,
+    zip_safe=False,
+)